6-(4-Nitrobenzoyl)-2,3-dimethyl-3,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine → 6-(4-Aminobenzoyl)-2,3-dimethyl-3,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine

HRID 1354

反応式

HRID 1354 の反応式
[N+:1]([C:4]1[CH:27]=[CH:26][C:7]([C:8]([N:10]2[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[C:14]3[N:21]=[C:22]([CH3:25])[N:23]([CH3:24])[C:13]=3[CH2:12][CH2:11]2)=[O:9])=[CH:6][CH:5]=1)([O-])=O>CO.[C].[Pd]>[NH2:1][C:4]1[CH:27]=[CH:26][C:7]([C:8]([N:10]2[C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=3[C:14]3[N:21]=[C:22]([CH3:25])[N:23]([CH3:24])[C:13]=3[CH2:12][CH2:11]2)=[O:9])=[CH:6][CH:5]=1

参加物

4

反応物 1

HCID 699555616-(4-Nitrobenzoyl)-2,3-dimethyl-3,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine

生成物 1

HCID 699556416-(4-Aminobenzoyl)-2,3-dimethyl-3,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

A 1.421 g portion of 6-(4-nitrobenzoyl)-2,3-dimethyl-3,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine was dissolved in 50 ml of methyl alcohol, and the solution was mixed with 300 mg of palladium-carbon and subjected to hydrogenation under normal pressure. After completion of the hydrogen absorption, the reaction mixture was subjected to filtration and the resulting filtrate was concentrated to obtain 571 mg of 6-(4-aminobenzoyl)-2,3-dimethyl-3,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine.

後処理

  1. customAfter completion of the hydrogen absorption
  2. filtrationthe reaction mixture was subjected to filtration
  3. concentrationthe resulting filtrate was concentrated

出典と根拠

ORDレコード
ord-b911c15a1a684981b9d7562f530a2f04
出典データセット
uspto-grants-1998_03
特許番号
US05723606

関連ノート

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