8-[2-(6-Methoxy-[1,5]naphthyridin-4-yl)ethyl]-1,4-dioxa-spiro[4.5]decan-8-ol → 4-Hydroxy-4-[2-(6-methoxy-[1,5]naphthyridin-4-yl)ethyl]-cyclohexanone

HRID 1354213ノート

反応式

HRID 1354213 の反応式
[CH3:1][O:2][C:3]1[N:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[C:6]2[CH2:13][CH2:14][C:15]1([OH:25])[CH2:24][CH2:23][C:18]2(OCC[O:19]2)[CH2:17][CH2:16]1>C1COCC1.O.CC(O)=O>[OH:25][C:15]1([CH2:14][CH2:13][C:6]2[C:5]3[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[N:4]=3)[N:9]=[CH:8][CH:7]=2)[CH2:24][CH2:23][C:18](=[O:19])[CH2:17][CH2:16]1

参加物

3

反応物 1

HCID 211046648-[2-(6-Methoxy-[1,5]naphthyridin-4-yl)ethyl]-1,4-dioxa-spiro[4.5]decan-8-ol

生成物 1

HCID 211046474-Hydroxy-4-[2-(6-methoxy-[1,5]naphthyridin-4-yl)ethyl]-cyclohexanone

試薬・触媒・溶媒 1

HCID 21877175AcOH THF water溶媒

実験手順

A solution of 8-[2-(6-methoxy-[1,5]naphthyridin-4-yl)ethyl]-1,4-dioxa-spiro[4.5]decan-8-ol (960 mg, 2.79 mmol) in THF/H2O/AcOH (2:2:3, 22 ml) was stirred overnight at 65° C. The reaction mixture was concentrated and purified by chromatography on silica gel (EtOAc).

後処理

  1. concentrationThe reaction mixture was concentrated
  2. custompurified by chromatography on silica gel (EtOAc)

出典と根拠

ORDレコード
ord-ef1a6486a5f048c48395fed3cef70c37
出典データセット
uspto-grants-2007_05
特許番号
US07223776B2

反応ノート

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