HCID 11298596、化合物 → HCID 21104595、化合物
反応式
[O:1]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][NH:12][CH2:13][C:14]3[CH2:15][NH:16][CH2:17][CH2:18][CH:19]=3)=[CH:10][C:5]=2[O:4][CH2:3][CH2:2]1.[CH3:20][O:21][C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[N:28]=[CH:27][CH:26]=[C:25]2[CH:32]1[CH2:34][O:33]1>CCO>[O:1]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][NH:12][CH2:13][C:14]3[CH2:15][N:16]([CH2:34][CH:32]([C:25]4[C:24]5[C:29](=[CH:30][CH:31]=[C:22]([O:21][CH3:20])[CH:23]=5)[N:28]=[CH:27][CH:26]=4)[OH:33])[CH2:17][CH2:18][CH:19]=3)=[CH:10][C:5]=2[O:4][CH2:3][CH2:2]1参加物
4
実験手順
A solution of (2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-(1,2,5,6-tetrahydro-pyridin-3-ylmethyl)-amine (0.06 g, 0.23 mmol) and 6-methoxy-4-oxiranylquinoline (0.06 g, 0.29 mmol) in EtOH (2 ml) was heated at 80° C. for 14 hours. The reaction mixture was concentrated and the residue was purified by chromatography on silica gel (DCM/MeOH 9/1).
後処理
- concentrationThe reaction mixture was concentrated