Ethanol → HCID 178517509、化合物
反応式
CO[C:3]([CH:5]1[CH2:9][CH2:8][CH2:7][C:6]1=[O:10])=O.[F:11][C:12]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:13]=1[C:14]([NH2:16])=[NH:15].[CH2:22](O)C>>[Cl:21][C:18]1[CH:19]=[CH:20][C:12]([F:11])=[C:13]([C:14]2[N:16]=[C:6]([OH:10])[C:5]3[CH2:3][CH2:22][CH2:7][CH2:8][C:9]=3[N:15]=2)[CH:17]=1参加物
4
反応条件
- 温度
- 80 °C
実験手順
To a solution of methyl-2-oxocyclopentane carboxylate (2 g, 11.8 mmol, 1 eq), in dry ethanol (20 ml) was added a solution of 2-fluoro-5-chlorobenzamidine (2.04 g, 11.8 mmol, 1 eq) in ethanol (20 ml) and the reaction mixture was heated to 80° C. overnight. The reaction mixture was cooled to rt and the solvent was removed in vacuo to afford a crude residue which was purified by recrystallization from hot ethyl acetate to afford 2-(5-chloro-2-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-4-ol (2.56 g, 78%) as a white solid.