tert-Butyl (2,3-dihydroxypropyl)methylcarbamate → tert-butyl N-methyl-N-(2-oxoethyl)carbamate

HRID 1354525ノート

反応式

HRID 1354525 の反応式
[C:1]([N:8]([CH3:14])[CH2:9][CH:10]([OH:13])CO)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]>O>[C:1]([N:8]([CH3:14])[CH2:9][CH:10]=[O:13])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:2]

参加物

3

反応物 1

HCID 17878865tert-Butyl (2,3-dihydroxypropyl)methylcarbamate

生成物 1

HCID 10725881tert-butyl N-methyl-N-(2-oxoethyl)carbamate収率 79%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of N-Boc-N-methyl-1-amino-2,3-propandiol (20g, 0.097 mol) in water (100 ml) was added KIO4 (24.68g, 0.108 mol). The reaction mixture was stirred for 2.5 hr under an atmosphere of nitrogen and then filtered. The filtrate was extracted with chloroform (5×50 ml). The resulting chloroform extracts are dried over MgSO4, filtered, and evaporated to dryness. The title compound 13.26g (79%) was isolated as a clear oil (bp 76-80° C. at 0.5 mm Hg).

後処理

  1. filtrationfiltered
  2. extractionThe filtrate was extracted with chloroform (5×50 ml)
  3. dry with materialThe resulting chloroform extracts are dried over MgSO4
  4. filtrationfiltered
  5. customevaporated to dryness

出典と根拠

ORDレコード
ord-bdb416062209445ab264f217412f1bea
出典データセット
uspto-grants-2007_05
特許番号
US07223833B1

反応ノート

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