1,4-Dioxane hydrochloride → 2-(4-Chloro-2-oxo-1,2-dihydro-pyridin-3-yl)-7-methyl-3H-benzimidazole-5-carbonitrile

HRID 1354607

反応式

HRID 1354607 の反応式
I[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([O:8]C)[C:3]=1[C:10]1[NH:11][C:12]2[CH:18]=[C:17]([C:19]#[N:20])[CH:16]=[C:15]([CH3:21])[C:13]=2[N:14]=1.O1CCOCC1.[ClH:28]>>[Cl:28][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[C:3]=1[C:10]1[NH:11][C:12]2[CH:18]=[C:17]([C:19]#[N:20])[CH:16]=[C:15]([CH3:21])[C:13]=2[N:14]=1

参加物

3

反応物 2

HCID 204431481,4-Dioxane hydrochlorideHCID 220210132-(4-Iodo-2-methoxy-pyridin-3-yl)-7-methyl-3H-benzimidazole-5-carbonitrile

生成物 1

HCID 1356816422-(4-Chloro-2-oxo-1,2-dihydro-pyridin-3-yl)-7-methyl-3H-benzimidazole-5-carbonitrile

反応条件

温度
80 °C

実験手順

A suspension of 2-(4-iodo-2-methoxy-pyridin-3-yl)-7-methyl-3H-benzimidazole-5-carbonitrile (1.8 g, 4.63 mmol) in 4 M HCl dioxane (40 mL) was heated to 80° C. for 6 h and cooled to room temperature. The precipitate was filtered and dried. The crude product (1.08 g, 82%) was used for the next step without purification. LRMS (neg. ESI, (M−H)−) m/z 283.

後処理

  1. temperaturecooled to room temperature
  2. filtrationThe precipitate was filtered
  3. customdried
  4. customThe crude product (1.08 g, 82%) was used for the next step without purification

出典と根拠

ORDレコード
ord-1e4f7bb0be984132832467b73edb6a6c
出典データセット
uspto-grants-2007_05
特許番号
US07223757B2

関連ノート

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