(2-Chloro-6-methoxypyridin-4-yl)methanol → 2-Chloro-6-methoxypyridine-4-carbaldehyde
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][OH:9])[CH:5]=[C:4]([O:10][CH3:11])[N:3]=1.C1C=C[NH+]=CC=1.[O-][Cr](Cl)(=O)=O>C(Cl)Cl.CCOCC>[Cl:1][C:2]1[CH:7]=[C:6]([CH:5]=[C:4]([O:10][CH3:11])[N:3]=1)[CH:8]=[O:9]参加物
5
実験手順
To a solution of (2-chloro-6-methoxypyridin-4-yl)methanol (1.73 g, 9.97 mmole) from the protocol immediately above in CH2Cl2 (40 ML) was added PCC (2.58 g, 11.96 mmole) all at once at RT. After 60 hr the mixture was diluted with Et2O and filtered through a plug of Celite®. The filtrate was concentrated to give the titled compound as a tan-yellow solid which was sufficiently pure for use in the next step. 1H-NMR (500 MHz, CDCl3) δ9.96 (s, 1H), 7.32 (s, 1H), 7.06 (s, 1H), 4.00 (s, 3H).
後処理
- filtrationfiltered through a plug of Celite®
- concentrationThe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-d6292a28800643dc941ebe6fcadcc399
- 出典データセット
- uspto-grants-2003_07
- 特許番号
- US06586423B2
反応ノート
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