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2-(Benzenesulfonyl)-3-phenyloxaziridine → 2-(Methylsulfinyl)pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Benzenesulfonyl)-3-phenyloxaziridine | HCID 320405 | — |
| 反応物 | 2-(Methylsulfanyl)pyrimidine | HCID 522772 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-(Methylsulfinyl)pyrimidine | HCID 11400832 | — |
反応手順
The methylsulfanyl-pyrimidine compound of formula (83) is reacted with an oxidising agent, preferably 3-phenyl-2-(phenylsulfonyl)oxaziridine, in an organic solvent, preferably dichloromethane, at room temperature. The product of formula (84), a methanesulfinyl-pyrimidine derivative, is isolated by conventional means, and preferably reacted in the next step without further purification. The product of formula (84) may, however, be additionally purified by means of chromatography or recrystallisation.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06586441B2 |
| 出典データセット | uspto-grants-2003_07 |
| ORD ID | ord-224b15c6ee9741c48c8a184c2ab8484f |
| 出典メモ | uspto-grants-2003_07 |