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Potassium Carbonate → 2-Amino-4-(3-fluoro-phenyl)-6-methylsulfanyl-pyrimidine-5-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-Fluorophenylboronic acid | HCID 2733986 | — |
| 反応物 | 2-Amino-4-chloro-6-methylsulfanyl-pyrimidine-5-carbonitrile | HCID 18507260 | — |
| 触媒 | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-Amino-4-(3-fluoro-phenyl)-6-methylsulfanyl-pyrimidine-5-carbonitrile | HCID 18507679 | — |
反応手順
From 2-amino-4-chloro-6-methylsulfanyl-pyrimidine-5-carbonitrile, m-fluorobenzeneboronic acid, tetrakis(triphenylphosphine)palladium(O) and potassium carbonate in toluene. EI-MS m/e (%): 260 (M+, 40), 259 ([M—H]+, 100).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06586441B2 |
| 出典データセット | uspto-grants-2003_07 |
| ORD ID | ord-d2230b2a704e403d8e597ab060ee818d |
| 出典メモ | uspto-grants-2003_07 |