Potassium Carbonate → N-Boc-N-methylethylenediamine

HRID 1356451ノート

反応式

HRID 1356451 の反応式
[C:1]([O:5][C:6](=[O:18])[N:7]([CH3:17])[CH2:8][CH2:9][NH:10]C(=O)C(F)(F)F)([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[NH2:10][CH2:9][CH2:8][N:7]([CH3:17])[C:6](=[O:18])[O:5][C:1]([CH3:2])([CH3:3])[CH3:4]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 10635722Methyl-[2-(2,2,2-trifluoro-acetylamino)-ethyl]-carbamic acid tert-butyl ester

生成物 1

HCID 2756424N-Boc-N-methylethylenediamine収率 70%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of tert-butyl(methyl)[2-[(2,2,2-trifluoroacetyl)amino]ethyl]carbamate (1 g) in methanol (10 ml) in an ice bath was added aqueous 10% potassium carbonate (5 ml). After addition, the reaction mixture was warmed to room temperature and stirring was continued for additional 20 hr. The reaction mixture was concentrated and the residue was dissolved in ethyl acetate. The insoluble material was removed by filtration and the filtrate was concentrated to obtain the titled compound (451 mg).

後処理

  1. additionAfter addition
  2. concentrationThe reaction mixture was concentrated
  3. dissolutionthe residue was dissolved in ethyl acetate
  4. customThe insoluble material was removed by filtration
  5. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-bf33dcfdf58a4d7faa9109b1524ea199
出典データセット
uspto-grants-2003_07
特許番号
US06586475B1

反応ノート

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