Potassium Carbonate → Ethyl 7-[(2-aminoethyl)(methyl)amino]heptanoate

HRID 1356454ノート

反応式

HRID 1356454 の反応式
[CH3:1][N:2]([CH2:14][CH2:15][NH:16]C(=O)C(F)(F)F)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[NH2:16][CH2:15][CH2:14][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 18508347Ethyl 7-[methyl-[2-[(2,2,2-trifluoroacetyl)amino]ethyl]amino]heptanoate

生成物 1

HCID 18508360Ethyl 7-[(2-aminoethyl)(methyl)amino]heptanoate収率 86.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of ethyl 7-[methyl-[2-[(2,2,2-trifluoroacetyl)amino]ethyl]amino]heptanoate (4.89 g) in ethanol (80 ml) in an ice bath was added 10% aqueous potassium carbonate (30 ml) and stirring was continued for 20 hr. The reaction mixture was concentrated and the residue was dissolved in ethyl acetate. The insoluble material was removed by filtration and the filtrate was concentrated to obtain the titled compound (3 g)

後処理

  1. concentrationThe reaction mixture was concentrated
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. customThe insoluble material was removed by filtration
  4. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-24b867b8648744bb9659eaa0bd78a8fe
出典データセット
uspto-grants-2003_07
特許番号
US06586475B1

反応ノート

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