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Methanol → (s)-3,4-Epoxybutyric acid tetrabutylammonium salt
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Tetrabutylammonium Hydroxide | HCID 2723671 | — |
| 反応物 | (3S)-3-acetyloxy-4-bromobutanoic acid | HCID 2733880 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (s)-3,4-Epoxybutyric acid tetrabutylammonium salt | HCID 9841041 | — |
反応手順
To a 2 l of three-necked flask equipped with thermometer, pH meter and mechanical stirrer were charged distilled water (1 l), (S)-3-acetoxy-4-bromobutyric acid (90 g, 0.4 mol) and tetrabutylammonium hydroxide, 1.0 M in methanol (1.2 l, 1.2 mol). The reaction mixture was stirred at 0˜5° C. for 2 hours to afford (S)-3,4-epoxybutyric acid tetrabutyl ammonium salt. Over 99% of conversion was detected by NMR.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06586616B1 |
| 出典データセット | uspto-grants-2003_07 |
| ORD ID | ord-f1e369a68aa246b19e9fa568ed7e6476 |
| 出典メモ | uspto-grants-2003_07 |