Octylamine → 3-Methoxybenzyl-3-octyl thiourea

HRID 1356606

反応式

HRID 1356606 の反応式
[CH2:1]([NH2:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[CH3:10][O:11][C:12]1[CH:13]=[C:14]([CH:19]=[CH:20][CH:21]=1)[CH2:15][N:16]=[C:17]=[S:18]>C(O)C>[CH3:10][O:11][C:12]1[CH:13]=[C:14]([CH:19]=[CH:20][CH:21]=1)[CH2:15][NH:16][C:17]([NH:9][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])=[S:18]

参加物

4

反応物 2

HCID 8143OctylamineHCID 1265123-Methoxybenzyl isothiocyanate

生成物 1

HCID 120820563-Methoxybenzyl-3-octyl thiourea

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
4 °C

実験手順

N-Octyl amine (3.09 g, 23.9 mmol) in 83 ml ethanol at 40° C. was reacted with an excess of 3-methoxybenzyl isothiocyanate (4.7 g, 26.2 mmol) for 2 h under N2 with stirring, then transferred to a 100 ml beaker, cooled to 4° C. and the crystals filtered off using Whatman 541 filter paper. The filtrate was evaporated to 20 ml and cooled to 4° C. to obtain a second crop of crystals. The remaining supernatant was dried and weighed. The first and second crop of crystals yielded 6.32 g, or 85.5% of the theoretical amount of 1-(3-methoxybenzyl-3-octyl thiourea. Calculated elemental analysis of 1-(3-methoxybenzyl)-3-octyl thiourea: C, 66.19; H, 9.15; N, 9.08; S, 10.39. Found: C, 66.21; H, 9.04; N, 9.07; S, 10.59.

後処理

  1. filtrationthe crystals filtered off
  2. filtrationfilter paper
  3. customThe filtrate was evaporated to 20 ml
  4. temperaturecooled to 4° C.
  5. customto obtain a second crop of crystals
  6. customThe remaining supernatant was dried

出典と根拠

ORDレコード
ord-52b499c6c75140a385e535ac81ad0e10
出典データセット
uspto-grants-2003_07
特許番号
US06586628B2

関連ノート

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