Acetic Anhydride → (4-Chloro-6-methylpyridin-2-yl)methyl acetate

HRID 1357030ノート

反応式

HRID 1357030 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[N+:5]([O-])=[C:4]([CH3:10])[CH:3]=1.[C:11]([O:14]C(=O)C)(=[O:13])[CH3:12]>>[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([CH2:10][O:14][C:11](=[O:13])[CH3:12])[CH:3]=1

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 5878434-Chloro-2,6-dimethylpyridine 1-oxide

生成物 1

HCID 18505252(4-Chloro-6-methylpyridin-2-yl)methyl acetate

実験手順

4.0 g (25.4 mmol) of 4-chloro-2,6-dimethylpyridine-1-oxide was dissolved in 12 ml of acetic anhydride. The resultant solution was gradually heated to raise the temperature to the reflux temperature, and the solution was then stirred overnight at the same temperature. The reacted solution was then condensed under reduced pressure to obtain a crude product of acetic 4-chloro-6-methyl-2-pyridinylmethyl ester.

後処理

  1. temperatureto raise the temperature to the reflux temperature
  2. customcondensed under reduced pressure

出典と根拠

ORDレコード
ord-b874bf9cc70649c696331d3670e0b7f4
出典データセット
uspto-grants-2003_07
特許番号
US06589967B1

反応ノート

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