化工社化工社 化学情報印刷レポート · 研究参考用
4-Ethylbenzene-1-sulfonyl chloride → (2RS,5SR)-[1-(4-Ethyl-benzenesulfonyl)-5-(4-fluoro-phenyl)-pyrrolidin-2-yl]-methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Ethylbenzene-1-sulfonyl chloride | HCID 570959 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 反応物 | methyl (2RS,5SR)-5-(4-fluoro-phenyl)-pyrrolidine-2-carboxylate | HCID 67257147 | — |
| 反応物 | methyl (2RS,5SR)-5-(4-fluoro-phenyl)-1-(4-ethyl-benzenesulfonyl)-pyrrolidine-2-carboxylate | HCID 86584369 | — |
| 生成物 | (2RS,5SR)-[1-(4-Ethyl-benzenesulfonyl)-5-(4-fluoro-phenyl)-pyrrolidin-2-yl]-methanol | HCID 69596851 | — |
反応手順
The title compound, pale yellow oil, MS: m/e=363 (M+) was prepared in accordance with the general methods of example 1d and 84a from methyl (2RS,5SR)-5-(4-fluoro-phenyl)-pyrrolidine-2-carboxylate and 4-ethyl-benzenesulfonyl chloride and subsequent reduction of methyl (2RS,5SR)-5-(4-fluoro-phenyl)-1-(4-ethyl-benzenesulfonyl)-pyrrolidine-2-carboxylate with lithium aluminum hydride according to the general method of example 2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06589978B2 |
| 出典データセット | uspto-grants-2003_07 |
| ORD ID | ord-a5fdca9f330045f7bba2afe8e81584c8 |
| 出典メモ | uspto-grants-2003_07 |