Bromine → 5-Bromo-6-methoxy-naphthalene-2-carbonitrile

HRID 1357284

反応式

HRID 1357284 の反応式
[Br:1]Br.[CH3:3][O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[CH:11]=[C:10]([C:15]#[N:16])[CH:9]=[CH:8]2>CC(O)=O>[Br:1][C:6]1[C:5]([O:4][CH3:3])=[CH:14][CH:13]=[C:12]2[C:7]=1[CH:8]=[CH:9][C:10]([C:15]#[N:16])=[CH:11]2

参加物

4

反応物 2

HCID 24408BromineHCID 3491736-Methoxynaphthalene-2-carbonitrile

生成物 1

HCID 185053355-Bromo-6-methoxy-naphthalene-2-carbonitrile収率 88%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

Bromine (7.0 mL, 0.137 mol) in 100 mL of glacial HOAc was added under nitrogen dropwise over 4 h to a solution of 6-methoxy-naphthalene-2-carbonitrile (25.02 g, 0.137 mol) in 700 mL of glacial HOAc at room temperature. After the addition the reaction was stirred at room temperature overnight. The solid that formed was collected by filtration, rinsed with glacial HOAc and dried under reduced pressure to give 5-bromo-6-methoxy-naphthalene-2-carbonitrile (31.35 g, 88%) as a white solid, mp 177-178° C.

後処理

  1. additionAfter the addition the reaction
  2. customThe solid that formed
  3. filtrationwas collected by filtration
  4. washrinsed with glacial HOAc
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-74ae69ad48b24a59abd662eb5ca083ec
出典データセット
uspto-grants-2003_07
特許番号
US06589970B2

関連ノート

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