p-Toluenesulfonic acid monohydrate → HCID 91107959、化合物
反応式
O.C1(C)C=CC(S(O)(=O)=O)=CC=1.[OH:13][C@:14]1([C:30]([O:32][CH3:33])=[O:31])[CH2:24][C@@H:23]([O:25][S:26]([CH3:29])(=[O:28])=[O:27])[C@@H:17]2[O:18]C(C)(C)[O:20][C@@H:16]2[CH2:15]1>CO>[OH:13][C@:14]1([C:30]([O:32][CH3:33])=[O:31])[CH2:24][C@@H:23]([O:25][S:26]([CH3:29])(=[O:27])=[O:28])[C@H:17]([OH:18])[C@H:16]([OH:20])[CH2:15]1参加物
4
実験手順
Para-toluenesulfonic acid monohydrate (100 mg, 0.526 mmol) was added to a room temperature solution of Example 17A in methanol (50 mL). After stirring overnight, the reaction mixture was concentrated and the concentrate was purified by flash column chromatography using ethyl acetate to afford 3.96 g (78%) of the desired product as a colorless oil.