Piperazine → 2-[(2,3-Dimethoxybenzyl)Oxy]-6-(1-Piperazinyl)Pyrazine

HRID 1357615

反応式

HRID 1357615 の反応式
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([O:16][CH3:17])[C:11]=2[O:18][CH3:19])[N:3]=1.COC1C(OC)=CC=CC=1CO.[NH:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1.C([O-])([O-])=O.[K+].[K+]>>[CH3:19][O:18][C:11]1[C:12]([O:16][CH3:17])=[CH:13][CH:14]=[CH:15][C:10]=1[CH2:9][O:8][C:4]1[CH:5]=[N:6][CH:7]=[C:2]([N:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)[N:3]=1

参加物

5

反応物 4

HCID 4837PiperazineHCID 11430Potassium CarbonateHCID 797382,3-Dimethoxybenzyl alcoholHCID 181869272-Chloro-6-[(2,3-dimethoxybenzyl)oxy]pyrazine

生成物 1

HCID 181868952-[(2,3-Dimethoxybenzyl)Oxy]-6-(1-Piperazinyl)Pyrazine

実験手順

The title compound was prepared according to the procedure of example 50, step 2, starting from 2-chloro-6-[(2,3-dimethoxybenzyl)oxy]pyrazine (2.51 g, 8.93 mmol; obtained according to the procedure of example 50, step 1, starting from 2,3-dimethoxybenzyl alcohol), piperazine (2.38 g, 27.7 mmol) and K2CO3 (1.23 g, 8.9 mmol). The yield of the title compound was 1.66 g (56%) which was obtained as an oil. Purity 100% (HPLC). MS m/z 331 (M+H)+. HRMS m/z calcd for C17H22N4O3 (M)+330.1692, found 330.1690.

後処理

  1. customThe title compound was prepared
  2. customobtained
  3. customwas obtained as an oil

出典と根拠

ORDレコード
ord-1179678ce1fa435a9b773a2acb168fe7
出典データセット
uspto-grants-2003_07
特許番号
US06593330B2

関連ノート

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