Piperazine → 2-(4-Phenoxybutoxy)-6-(1-Piperazinyl)Pyrazine

HRID 1357616

反応式

HRID 1357616 の反応式
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:3]=1.O(CCCCO)C1C=CC=CC=1.[NH:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1.C([O-])([O-])=O.[K+].[K+]>>[O:13]([CH2:12][CH2:11][CH2:10][CH2:9][O:8][C:4]1[CH:5]=[N:6][CH:7]=[C:2]([N:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)[N:3]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

5

反応物 4

HCID 4837PiperazineHCID 11430Potassium CarbonateHCID 2196834-Phenoxybutan-1-olHCID 181869252-Chloro-6-(4-phenoxybutoxy)pyrazine

生成物 1

HCID 181867762-(4-Phenoxybutoxy)-6-(1-Piperazinyl)Pyrazine

実験手順

The title compound was prepared according to the procedure of example 50, step 2, starting from 2-chloro-6-(4-phenoxybutoxy)pyrazine (1.99 g, 7.14 mmol; obtained according to the procedure of example 50, step 1, starting from 4-phenoxy-1-butanol*), piperazine (1.84 g, 21.4 mmol) and K2CO3 (0.99 g, 7.14 mmol). The yield of the title compound was 1.52 g (65%) which was obtained as an oil. Purity100% (HPLC). MS m/z 329 (M+H)+. HRMS m/z calcd for C18H24N4O2 (M)+ 328.1899, found 328.1894.

後処理

  1. customThe title compound was prepared
  2. customobtained
  3. customwas obtained as an oil

出典と根拠

ORDレコード
ord-37561d403c9f47eabbf195e4a9ff0971
出典データセット
uspto-grants-2003_07
特許番号
US06593330B2

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