Piperazine → HCID 18186929、化合物

HRID 1357637ノート

反応式

HRID 1357637 の反応式
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([O:8][CH2:9][C:10]2[CH:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=3)[O:12][C:11]=2[CH3:22])[N:3]=1.ClC1C=CC(C2OC(C)=C(CO)C=2)=CC=1.[NH:38]1[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]1.C([O-])([O-])=O.[K+].[K+]>>[Cl:21][C:18]1[CH:19]=[CH:20][C:15]([C:13]2[O:12][C:11]([CH3:22])=[C:10]([CH2:9][O:8][C:4]3[CH:5]=[N:6][CH:7]=[C:2]([N:38]4[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]4)[N:3]=3)[CH:14]=2)=[CH:16][CH:17]=1

参加物

5

反応物 4

HCID 4837PiperazineHCID 11430Potassium CarbonateHCID 7245332[5-(4-Chlorophenyl)-2-methylfuran-3-yl]methanolHCID 18186841HCID 18186841、化合物

生成物 1

HCID 18186929HCID 18186929、化合物

実験手順

The title compound was prepared according to the procedure of example 50, step 2, starting from 2-chloro-6-[5-(4-chlorophenyl)-2-methylfuran-3-ylmethoxy]pyrazine [3.14 g, 9.39 mmol; obtained according to the procedure of example 50, step 1, starting from 5-(4-chlorophenyl)-3-hydroxymethyl-2-methylfuran], piperazine (2.47 g, 28.6 mmol) and K2CO3 (1.36 g, 9.86 mmol) with the exception that the final filtration through alumina was omitted. The yield of the of the title compound was 2.11 g (58%) which was obtained as a beige colored solid. Purity 100% (HPLC). MS m/z 384 (M)+. HRMS m/z calcd for C20H21ClN4O2 (M)+ 384.1353, found 384.1357.

後処理

  1. customobtained
  2. filtrationfiltration through alumina
  3. customwas obtained as a beige colored solid

出典と根拠

ORDレコード
ord-e6f35c6d07e24413aefabc6bfbab6242
出典データセット
uspto-grants-2003_07
特許番号
US06593330B2

反応ノート

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