化工社化工社 化学情報印刷レポート · 研究参考用
Calcium Carbonate → 2,1,3-Benzothiadiazol-5-ylmethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Calcium Carbonate | HCID 10112 | — |
| 反応物 | 5-(Bromomethyl)-2,1,3-benzothiadiazole | HCID 591004 | — |
| 溶媒 | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| 生成物 | 2,1,3-Benzothiadiazol-5-ylmethanol | HCID 2776294 | 76.4% |
反応手順
5-Bromomethylbenzo-2,1,3-thiadiazole (4.8 g) and calcium carbonate (10 g) were heated at reflux in 1:1 dioxane/water (120 mL) for 3 hours. The solvents were evaporated and the residue was partitioned between 2N hydrochloric acid and methylene 6 3 chloride. The organic layers were dried (magnesium sulfate), evaporated and chromatographed on silica gel eluting with 1:1 ethyl acetate/hexane to provide 2.66 g of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06593335B1 |
| 出典データセット | uspto-grants-2003_07 |
| ORD ID | ord-029bc9b646b04e428b99707522c2021c |
| 出典メモ | uspto-grants-2003_07 |