Bromine → 3-Bromo-2-ethyl-imidazo[1,2-a]pyridine
反応式
[CH2:1]([C:3]1[N:4]=[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][N:6]2[CH:11]=1)[CH3:2].[Br:12]Br>C(O)C.O>[Br:12][C:11]1[N:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]2=[N:4][C:3]=1[CH2:1][CH3:2]参加物
5
実験手順
To a solution of 2-ethyl-imidazo[1,2-a]pyridine (2.17 g, 14.9 mmol) in ethanol (25 mL) was added bromine (2.0 g, 12.5 mmol) in water (5 mL) dropwise at rt. After stirring at rt for 4h, ethanol was evaporated under reduced pressure. The residue was basified with aqueous sodium bicarbonate and extracted with methylene chloride (3×). The organic phase was washed with brine and dried over anhydrous magnesium sulfate. Concentration followed by flash chromatography eluting with 20 % ethyl acetate in hexanes, followed by 50% ethyl acetate in hexanes afforded the title compound (1.88 g) as a viscous oil.
後処理
- customwas evaporated under reduced pressure
- extractionextracted with methylene chloride (3×)
- washThe organic phase was washed with brine
- dry with materialdried over anhydrous magnesium sulfate
- concentrationConcentration
- washeluting with 20 % ethyl acetate in hexanes
出典と根拠
- ORDレコード
- ord-561312f5aed24479b2ebee4db8301ee2
- 出典データセット
- uspto-grants-2003_07
- 特許番号
- US06593346B2
反応ノート
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