4-Fluoroaniline → N-(4-fluorophenyl)-2-(3-methoxyphenyl)acetamide

反応式

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][C:10](Cl)=[O:11])[CH:6]=[CH:7][CH:8]=1.[F:13][C:14]1[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=1>>[F:13][C:14]1[CH:20]=[CH:19][C:17]([NH:18][C:10](=[O:11])[CH2:9][C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=2)=[CH:16][CH:15]=1

参加物

反応物 2

HCID 97314-Fluoroaniline

HCID 27332463-Methoxyphenylacetyl chloride

生成物 1

HCID 2704885N-(4-fluorophenyl)-2-(3-methoxyphenyl)acetamide収率 98%

実験手順

The title compound was prepared as described in Example 1.A, using 3-methoxyphenylacetyl chloride (3.29 g, 18.0 mmol) and 4-fluoroaniline (1.98 g, 18.0 mmol) to afford the title compound (4.57 g, 98% yield): ES-MS (m/z) 259.

後処理

customThe title compound was prepared

出典と根拠

ORDレコード: ord-775fbe5e6c5545b0a0de76ac2f0bc43a
出典データセット: uspto-grants-2003_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06593322B1

反応ノート

読み込み中…