Phosphorus oxychloride → HCID 18184384、化合物

HRID 1358264ノート

反応式

HRID 1358264 の反応式
O=[C:2]1[C:11]2[N:10]=[CH:9][N:8]=[CH:7][C:6]=2[CH:5]=[C:4]2[O:12][CH2:13][NH:14][CH:3]12.O=P(Cl)(Cl)[Cl:17]>>[Cl:17][C:2]1[C:11]2[N:10]=[CH:9][N:8]=[CH:7][C:6]=2[CH:5]=[C:4]2[O:12][CH:13]=[N:14][C:3]=12

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 69704031HCID 69704031、化合物

生成物 1

HCID 18184384HCID 18184384、化合物収率 22%

実験手順

A suspension of 4-oxo-3H-oxazolo[5,4-g]quinazoline (0.98 g, 5.24 mmol) in POCl3 (30 mL) is heated under reflux with vigorous stirring for 18 h, and then concentrated to dryness. The residue is partitioned between EtOAc and saturated aqueous NaHCO3 and the organic portion is worked up to give 4-chlorooxazolo[5,4-g]quinazoline (0.24 g, 22%) as a yellow solid which is used directly.

後処理

  1. temperatureis heated
  2. temperatureunder reflux
  3. concentrationconcentrated to dryness
  4. customThe residue is partitioned between EtOAc and saturated aqueous NaHCO3

出典と根拠

ORDレコード
ord-0d4db61eb5d440e8a3773f8ba3cafc8a
出典データセット
uspto-grants-2003_07
特許番号
US06596726B1

反応ノート

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