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4,6-Dichloro-2-cyclopropyl-5-(o-methoxyphenoxy)-pyrimidine → 4-tert.-butyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-cyclopropyl-pyrimidin-4-yl]-benzene-sulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4,6-Dichloro-2-cyclopropyl-5-(o-methoxyphenoxy)-pyrimidine | HCID 21979562 | — |
| 反応物 | p-t-Butylbenzenesulfonamide potassium | HCID 66748434 | — |
| 生成物 | 4-tert.-butyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-cyclopropyl-pyrimidin-4-yl]-benzene-sulfonamide | HCID 18184267 | — |
反応手順
According to the procedure described in Example 1g) 3.3 g 4,6-dichloro-2-cyclopropyl-5-(o-methoxyphenoxy)-pyrimidine (prepared according to procedures described in Example 1) was reacted with 4-tert.-butylphenylsulfonamide potassium salt to give 4.22 g 4-tert.-butyl-N-[6-chloro-5-(o-methoxyphenoxy)-2-cyclopropyl-pyrimidin-4-yl]-benzene-sulfonamide. LC-MS: tR=6.24 min, [M+1]+=488.23.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06596719B1 |
| 出典データセット | uspto-grants-2003_07 |
| ORD ID | ord-bb793a4f7b7e4309bb32a067284c8807 |
| 出典メモ | uspto-grants-2003_07 |