Ethanol → HCID 9855924、化合物

HRID 1358543ノート

反応式

HRID 1358543 の反応式
[C:1]([C:4]1[CH2:5][CH2:6][O:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[CH:10]=1)([OH:3])=[O:2].[CH2:15](O)[CH3:16]>S(=O)(=O)(O)O>[CH2:15]([O:2][C:1]([C:4]1[CH2:5][CH2:6][O:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[CH:10]=1)=[O:3])[CH3:16]

参加物

4

反応物 2

HCID 702EthanolHCID 11116823HCID 11116823、化合物

生成物 1

HCID 9855924HCID 9855924、化合物

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

A mixture of 8.2 g (0.043 mol) of 2,3-dihydro-4-carboxybenzoxepine in 150 ml of ethanol and 5 ml of concentrated sulphuric acid is brought to reflux for 6 hours. The reaction mixture is subsequently concentrated under reduced pressure and the residue is taken up in water. The combined mixture is extracted with ethyl acetate. The organic phase is then washed with sodium bicarbonate and then with water and dried over anhydrous sodium sulphate before being concentrated under reduced pressure. 8.5 g of an orange oil are thus obtained.

後処理

  1. temperatureto reflux for 6 hours
  2. concentrationThe reaction mixture is subsequently concentrated under reduced pressure
  3. extractionThe combined mixture is extracted with ethyl acetate
  4. washThe organic phase is then washed with sodium bicarbonate
  5. dry with materialwith water and dried over anhydrous sodium sulphate
  6. concentrationbefore being concentrated under reduced pressure

出典と根拠

ORDレコード
ord-f478c6f1b4a94736b09a56fd719e7e3a
出典データセット
uspto-grants-2003_07
特許番号
US06596758B1

反応ノート

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