化工社化工社 化学情報印刷レポート · 研究参考用
Sodium hydride → 4-Trifluoromethylthiobenzyl 4-trifluoromethylsulfonylphenyl ether
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 1-Chloro-4-(trifluoromethylsulfonyl)benzene | HCID 703324 | — |
| 反応物 | 4-((Trifluoromethyl)thio)benzenemethanol | HCID 2777870 | — |
| 生成物 | 4-Trifluoromethylthiobenzyl 4-trifluoromethylsulfonylphenyl ether | HCID 18185327 | 66.7% |
反応手順
4-(Trifluoromethylthio)benzyl alcohol (300 mg, 1.44 mmol) was coupled with 4-(trifluoromethylsulfonyl)chlorobenzene (370 mg, 1.51 mmol) using sodium hydride (65 mg, 60% dispersion in oil, 1.58 mmol) to give 400 mg of 4-trifluoromethylthiobenzyl 4-trifluoromethylsulfonylphenyl ether as a white solid. 1HNMR (360 MHz, DMSO-d6) δ 8.06 (d, J=8.4 Hz, 2H), 7.77 (d, J=8.4 Hz, 2H), 7.63 (d, J=8.4 Hz, 2H), 7.43 (d, J=8.4 Hz, 2H), 5.39 (s, 2H, OCH2).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06596772B1 |
| 出典データセット | uspto-grants-2003_07 |
| ORD ID | ord-66643039a25840489d0b0e062542870d |
| 出典メモ | uspto-grants-2003_07 |