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Diethylene Glycol → 2-(2-((Tert-butyldimethylsilyl)oxy)ethoxy)ethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethylene Glycol | HCID 8117 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Tert-butyldimethylsilane chloride | HCID 131722836 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-(2-((Tert-butyldimethylsilyl)oxy)ethoxy)ethanol | HCID 11117582 | 97.9% |
反応手順
20 g of diethyleneglycol is added to 9.05 g of sodium hydride in 320 cm3 of tetrahydrofuran, the reaction medium is agitated for 45 minutes, 28.3 g of dimethylterbutylsilane chloride is added, agitation is carried out for 3 hours while leaving the temperature to return to ambient. Extraction is carried out with ether, followed by washing with an aqueous solution of sodium bicarbonate, with salt water, drying and evaporating the solvent. 40.25 g of expected product is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06596885B2 |
| 出典データセット | uspto-grants-2003_07 |
| ORD ID | ord-90299c7a679946a99270dd0793685b67 |
| 出典メモ | uspto-grants-2003_07 |