Ammonia → Elpetrigine
反応式
[NH2:1][C:2]1[C:7]([C:8]2[CH:13]=[C:12]([Cl:14])[CH:11]=[C:10]([Cl:15])[C:9]=2[Cl:16])=[N:6][CH:5]=[C:4]([NH:17]C(=O)C)[N:3]=1.N>Cl.O>[NH2:1][C:2]1[C:7]([C:8]2[CH:13]=[C:12]([Cl:14])[CH:11]=[C:10]([Cl:15])[C:9]=2[Cl:16])=[N:6][CH:5]=[C:4]([NH2:17])[N:3]=1参加物
5
実験手順
A suspension of 2-amino-6-acetamido-3-(2,3,5-trichlorophenyl)pyrazine (2.97 g, 8.96×10−3 mole) in 12M hydrochloric acid (1.31 ml) and water (4.04 ml) was fluxed for 1.75 hrs. The cooled mixture was then basified with 0.880 aqueous ammonia (5 ml) and extracted with chloroform (3×50 ml). The combined chloroform extracts were dried over anhydrous magnesium sulphate, filtered and the filtrate evaporated down in vacuo at 80° C. Yield 2.29 g (88%), M.p. 178-180° C.
後処理
- extractionextracted with chloroform (3×50 ml)
- dry with materialThe combined chloroform extracts were dried over anhydrous magnesium sulphate
- filtrationfiltered
- customthe filtrate evaporated down in vacuo at 80° C
出典と根拠
- ORDレコード
- ord-e678911a49074da88ea60cab12336675
- 出典データセット
- uspto-grants-2003_07
- 特許番号
- US06599905B2
反応ノート
読み込み中…