HCID 18180220、化合物 → 2-Isopropylcarbonylamino-6-amino-3-(2,3,5-trichlorophenyl)pyrazine
反応式
[CH:1]([C:4]([NH:6][C:7]1[C:12]([C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[C:15]([Cl:20])[C:14]=2[Cl:21])=[N:11][CH:10]=[C:9]([NH:22]C(=O)C)[N:8]=1)=[O:5])([CH3:3])[CH3:2]>C(O)C>[CH:1]([C:4]([NH:6][C:7]1[C:12]([C:13]2[CH:18]=[C:17]([Cl:19])[CH:16]=[C:15]([Cl:20])[C:14]=2[Cl:21])=[N:11][CH:10]=[C:9]([NH2:22])[N:8]=1)=[O:5])([CH3:3])[CH3:2]参加物
3
反応条件
- 温度
- 55 °C
実験手順
Stannous chloride (0.182 g, 0.0096 mole) was added to the suspension of 2-isopropylcarbonylamino-6-acetamido-3-(2,3,5-trichlorophenyl)pyrazine (0.13 g, 3.24×10−4 mole), in absolute ethanol (6.50 ml) and the resulting mixture stirred at 50-60° C. for 1 hr 20 min. The reaction mixture was cooled and evaporated in vacuo. The residue was extracted with ethylacetate (3×20 ml), washed with water (2×20 ml), dried over anhydrous magnesium sulphate, filtered and the filtrate evaporated in vacuo. The residue was purified by ‘flash chromatography’ using chloroform:methanol, 99:1 as the eluent. Yield 0.046 g (40%), M.p. 105-108° C.