HCID 18182171、化合物 → HCID 18182389、化合物
反応式
C(O[CH:5]([C:12]1[CH:17]=[CH:16][N:15]=[C:14]([O:18][CH3:19])[CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)(=O)C.[H][H]>[C].[Pd].CO>[CH2:5]([C:12]1[CH:17]=[CH:16][N:15]=[C:14]([O:18][CH3:19])[CH:13]=1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1参加物
5
実験手順
5 g of 10% palladium carbon and 500 ml of methanol were added to 112 g of 4-(α-acetoxybenzyl)-2-methoxypyridine, followed by conducting hydrocracking in a hydrogen atmosphere. The catalyst was filtered off and the filtrate was evaporated. Then, the residue was neutralized by an aqueous saturated sodium bicarbonate solution and the mixture was extracted with ethyl acetate. The extract was washed with brine, dried over anhydrous magnesium sulfate and the solvent was removed, to give 73 g of the target compound.
後処理
- filtrationThe catalyst was filtered off
- customthe filtrate was evaporated
- extractionthe mixture was extracted with ethyl acetate
- washThe extract was washed with brine
- dry with materialdried over anhydrous magnesium sulfate
- customthe solvent was removed
出典と根拠
- ORDレコード
- ord-ddc1964fc4be444db073ca4c88cbb021
- 出典データセット
- uspto-grants-2003_07
- 特許番号
- US06599917B1
反応ノート
読み込み中…