Potassium Carbonate → (3R)-3-ethynyl-1-azabicyclo[2.2.2]octan-3-ol
反応式
[C:1]([C@:3]1([OH:11])[CH:8]2[CH2:9][CH2:10][N:5]([CH2:6][CH2:7]2)[CH2:4]1)#[CH:2].C([C@@H]([C@H](C([O-])=O)O)O)([O-])=O.C(=O)([O-])[O-].[K+].[K+]>O>[C:1]([C@:3]1([OH:11])[CH:8]2[CH2:9][CH2:10][N:5]([CH2:6][CH2:7]2)[CH2:4]1)#[CH:2]参加物
4
実験手順
15.6 g of (3R)-3-ethynyl-3-quinuclidinol +L-(+)-tartrate was dissolved in 150 ml of water and 20 g of anhydrous potassium carbonate was added little by little under stirring. The resulting crystal were collected by filtration, washed with water and then dried, to give 6.88 g of the title compound.
後処理
- filtrationThe resulting crystal were collected by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-ed782d19f4df4c6a9d28b0d3785c9ff5
- 出典データセット
- uspto-grants-2003_07
- 特許番号
- US06599917B1
反応ノート
読み込み中…