Acetone → 1-Methoxy-3-phenylpropan-2-one

HRID 1359416ノート

反応式

HRID 1359416 の反応式
CC(C)=O.[CH3:5][O:6][CH2:7][CH:8]([OH:16])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>CC(O)C>[CH3:5][O:6][CH2:7][C:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:16]

参加物

4

反応物 2

HCID 180AcetoneHCID 135125601-Methoxy-3-phenyl-2-propanol

生成物 1

HCID 117449711-Methoxy-3-phenylpropan-2-one収率 73.4%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

20.4 ml of a Jone's reagent was slowly added dropwise into 200 ml of an acetone solution containing 5.1 g of 1-methoxy-3-phenyl-2-propanol. After stirring for 30 minutes at room temperature, 30 ml of 2-propanol was slowly added to the reaction solution. After removing the solvent, water was added thereto and the mixture was extracted with ethyl acetate. The organic phase was washed with brine and the solvent was removed. The residue was subjected to silica gel column chromatography and elute with hexane/ethyl acetate (6:1), to give 3.7 g of the target compound.

後処理

  1. customAfter removing the solvent, water
  2. additionwas added
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe organic phase was washed with brine
  5. customthe solvent was removed
  6. washelute with hexane/ethyl acetate (6:1)

出典と根拠

ORDレコード
ord-476b05a3d40b4c35bc563713a6029d38
出典データセット
uspto-grants-2003_07
特許番号
US06599917B1

反応ノート

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