Sulfamic Acid → Pyrimido[5,4-g]pteridine

HRID 1359458

反応式

HRID 1359458 の反応式
N[C:2]1[N:7]=[C:6]([NH2:8])[C:5]([N:9]=O)=[C:4](N)[N:3]=1.N[C:13]1[N:18]=[C:17](N)[CH:16]=[C:15](O)[N:14]=1.S(=O)(=O)(O)N>O>[N:14]1[C:15]2[C:16](=[N:9][C:5]3[CH:4]=[N:3][CH:2]=[N:7][C:6]=3[N:8]=2)[CH:17]=[N:18][CH:13]=1

参加物

5

反応物 3

HCID 5987Sulfamic AcidHCID 705045-Nitroso-2,4,6-pyrimidinetriamineHCID 178507952HCID 178507952、化合物

生成物 1

HCID 18183250Pyrimido[5,4-g]pteridine

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
84 °C

実験手順

A mixture of 6.20 g of commercial 2,4,6-triamino-5-nitrosopyrimidine, 5.15 g of 2,4-diamino-6-hydroxypyrimidine and 3.92 g of sulfamic acid in 230 ml of water is finely stirred for one minute by means of an ULTRA-TURRAX® stirring rod and heated to a temperature in the range of from 82 to 86° C. The mixture is stirred at that temperature for 17 hours and then filtered over a laminated paper filter while still hot. The residue is washed with hot water until the pH of the washing water is above 4. After drying in vacuo at 110 ° C., there are obtained 10.28 g (75% of the theoretical yield) of a light-yellow powder of the pyrimido-[5,4-g]pteridine salt of formula IV, the acid being sulfamic acid.

後処理

  1. stirringstirring rod
  2. stirringThe mixture is stirred at that temperature for 17 hours
  3. filtrationfiltered over a laminated paper
  4. filtrationfilter while still hot
  5. washThe residue is washed with hot water until the pH of the washing water
  6. customAfter drying in vacuo at 110 ° C.
  7. customthere are obtained 10.28 g (75% of the

出典と根拠

ORDレコード
ord-9402a21072144e849d08900047dc3c6d
出典データセット
uspto-grants-2003_07
特許番号
US06600042B1

関連ノート

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