化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → 3-(2-Methylphenyl)propanoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 3-(2-Methylphenyl)propionic acid | HCID 30938 | — |
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-(2-Methylphenyl)propanoyl chloride | HCID 13029201 | — |
反応手順
A mixture of 2-methylhydrocinnamic acid (3.0 g, 18.3 mmole), oxalyl chloride (3.19 ml, 36.6 mmole) and methylene chloride (30 ml) was cooled in an ice bath and N,N-dimethylformamide (0.14 ml, 1.81 mmole) was added dropwise. The mixture was stirred at room temperature overnight. Concentration in vacuo gave 3-(2-methylphenyl)propanoyl chloride which was taken up in methylene chloride and used in the next step as a crude.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06600015B2 |
| 出典データセット | uspto-grants-2003_07 |
| ORD ID | ord-e73ff8e2d55a4b51a053c53a0659d534 |
| 出典メモ | uspto-grants-2003_07 |