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Salicyl Alcohol → [2-(2-Morpholinoethoxy)phenyl]methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Salicyl Alcohol | HCID 5146 | — |
| 反応物 | Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) | HCID 77210 | — |
| 溶媒 | Sodium Hydroxide | HCID 14798 | — |
| 生成物 | [2-(2-Morpholinoethoxy)phenyl]methanol | HCID 7164615 | — |
反応手順
A mixture of 2-hydroxybenzyl alcohol (1.295 g, 10.4 mmol) and 4-(2-chloroethyl)morpholine hydrochloride (1.94 g, 10.4 mmol) in 2N NaOH (10.5 mL) was stirred at rt for 14 hours. The precipitate was collected by vacuum filtration, washed with 1N NaOH, redissolved in DCM and washed with 1N NaOH. The aqueous layer was extracted with more DCM (2×). The combined DCM was dried and concentrated to give [2-(2-morpholin-4-yl-ethoxy)-phenyl]-methanol which was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06599902B2 |
| 出典データセット | uspto-grants-2003_07 |
| ORD ID | ord-7b584bb1f44649918b9acb5561442590 |
| 出典メモ | uspto-grants-2003_07 |