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Thionyl Chloride → 4-[2-(2-Chloromethyl-phenoxy)-ethyl]-morpholine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | [2-(2-Morpholinoethoxy)phenyl]methanol | HCID 7164615 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-[2-(2-Chloromethyl-phenoxy)-ethyl]-morpholine hydrochloride | HCID 18179952 | — |
反応手順
Thionyl chloride (5 mL, 2M in DCM) was added to a solution of [2-(2-morpholin-4-yl-ethoxy)-phenyl]-methanol (1.97 g, 8.3 mmol) in DCM (15 mL) at 0° C. The mixture was allowed to warm up to rt and stirred for 3 hours. The reaction was concentrated to give 4-[2-(2-chloromethyl-phenoxy)-ethyl]-morpholine hydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06599902B2 |
| 出典データセット | uspto-grants-2003_07 |
| ORD ID | ord-be00cb7769404c78a5a43fa97f876643 |
| 出典メモ | uspto-grants-2003_07 |