Piperidine → 3-[1-{3,5-Dimethyl-4-[2-oxo-2-((s)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-ethyl]-1h-pyrrol-2-yl}-meth-(z)-ylidene]-5-phenylmethanesulfonyl-1,3-dihydro-indol-2-one

HRID 1359777ノート

反応式

HRID 1359777 の反応式
[C:1]1([CH2:7][S:8]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH2:14]3)(=[O:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:21][C:22]1[C:26]([CH2:27][C:28](=[O:40])[N:29]2[CH2:33][CH2:32][CH2:31][C@H:30]2[CH2:34][N:35]2[CH2:39][CH2:38][CH2:37][CH2:36]2)=[C:25]([CH3:41])[NH:24][C:23]=1[CH:42]=O.N1CCCCC1>C(O)C>[CH3:21][C:22]1[C:26]([CH2:27][C:28](=[O:40])[N:29]2[CH2:33][CH2:32][CH2:31][C@H:30]2[CH2:34][N:35]2[CH2:39][CH2:38][CH2:37][CH2:36]2)=[C:25]([CH3:41])[NH:24][C:23]=1/[CH:42]=[C:14]1\[C:15](=[O:20])[NH:16][C:17]2[C:13]\1=[CH:12][C:11]([S:8]([CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)(=[O:10])=[O:9])=[CH:19][CH:18]=2

参加物

5

反応物 3

HCID 8082PiperidineHCID 21139221HCID 21139221、化合物HCID 880943273,5-Dimethyl-4-[2-oxo-2-((s)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-ethyl]-1h-pyrrole-2-carbaldehyde

生成物 1

HCID 590774823-[1-{3,5-Dimethyl-4-[2-oxo-2-((s)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-ethyl]-1h-pyrrol-2-yl}-meth-(z)-ylidene]-5-phenylmethanesulfonyl-1,3-dihydro-indol-2-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 5-phenylmethanesulfonyl-1,3-dihydro-indol-2-one (100 mg, 0.35 mmol), 3,5-dimethyl-4-[2-oxo-2-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-ethyl]-1H-pyrrole-2-carbaldehyde (110 mg, 1 eq.) and piperidine (0.5 eq.) in ethanol (2 mL) was stirred at rt for 48 hours. The reaction was concentrated, triturated with methanol, filtered and washed wit DCM to give the titled compound as a pale orange solid.

後処理

  1. concentrationThe reaction was concentrated
  2. customtriturated with methanol
  3. filtrationfiltered
  4. washwashed wit DCM

出典と根拠

ORDレコード
ord-62c45ba6a11345dfb83cc31995f68e80
出典データセット
uspto-grants-2003_07
特許番号
US06599902B2

反応ノート

読み込み中…