Piperidine → HCID 59077648、化合物

HRID 1359779ノート

反応式

HRID 1359779 の反応式
[C:1]1([CH2:7][S:8]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH2:14]3)(=[O:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:21][C@H:22]1[NH:27][C@@H:26]([CH3:28])[CH2:25][N:24]([C:29](=[O:40])[CH2:30][C:31]2[C:32]([CH3:39])=[C:33]([CH:37]=O)[NH:34][C:35]=2[CH3:36])[CH2:23]1.N1CCCCC1>C(O)C>[CH3:21][C@H:22]1[NH:27][C@@H:26]([CH3:28])[CH2:25][N:24]([C:29](=[O:40])[CH2:30][C:31]2[C:32]([CH3:39])=[C:33](/[CH:37]=[C:14]3\[C:15](=[O:20])[NH:16][C:17]4[C:13]\3=[CH:12][C:11]([S:8]([CH2:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)(=[O:10])=[O:9])=[CH:19][CH:18]=4)[NH:34][C:35]=2[CH3:36])[CH2:23]1

参加物

5

反応物 3

HCID 8082PiperidineHCID 21139221HCID 21139221、化合物HCID 88095588HCID 88095588、化合物

生成物 1

HCID 59077648HCID 59077648、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 5-phenylmethanesulfonyl-1,3-dihydro-indol-2-one (100 mg, 0.35 mmol), 4-[2-((3R,5S)-3,5-dimethyl-piperazin-1-yl)-2-oxo-ethyl]-3,5-dimethyl-1H-pyrrole-2-carbaldehyde (184 mg, 0.68 mmol) and piperidine (0.5 eq.) in ethanol (2 mL) was stirred at rt for 48 hours. The reaction was concentrated and triturated with acetone to give the titled compound as a pale orange-red solid.

後処理

  1. concentrationThe reaction was concentrated
  2. customtriturated with acetone

出典と根拠

ORDレコード
ord-57686fd5a15b4a058e70123a142ffecf
出典データセット
uspto-grants-2003_07
特許番号
US06599902B2

反応ノート

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