Water → (2-Bromo-4-methoxy-phenyl)-(4-ethyl-phenyl)-methanone

HRID 1359911ノート

反応式

HRID 1359911 の反応式
[CH3:1][O-:2].[Na+].[Br:4][C:5]1[CH:10]=[C:9](F)[CH:8]=[CH:7][C:6]=1[C:12]([C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH3:21])=[CH:16][CH:15]=1)=[O:13].O>CN(C=O)C>[Br:4][C:5]1[CH:10]=[C:9]([O:2][CH3:1])[CH:8]=[CH:7][C:6]=1[C:12]([C:14]1[CH:19]=[CH:18][C:17]([CH2:20][CH3:21])=[CH:16][CH:15]=1)=[O:13]

参加物

5

反応物 3

HCID 962WaterHCID 10942334Sodium Methoxide2 回HCID 43338337(2-Bromo-4-fluoro-phenyl)-(4-ethyl-phenyl)-methanone

生成物 1

HCID 58385812(2-Bromo-4-methoxy-phenyl)-(4-ethyl-phenyl)-methanone

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Sodium methoxide (10.5 g) is added portionwise to (2-bromo-4-fluoro-phenyl)-(4-ethyl-phenyl)-methanone (43.0 g) dissolved in DMF (200 mL). The solution is stirred overnight, before another portion of sodium methoxide (5.5 g) is added. After another 3 h of stirring, water is added and the resulting mixture is extracted with ethyl acetate. The organic phase is dried (sodium sulphate), the solvent is removed and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 20:1->9:1).

後処理

  1. additionis added
  2. extractionthe resulting mixture is extracted with ethyl acetate
  3. dry with materialThe organic phase is dried (sodium sulphate)
  4. customthe solvent is removed
  5. customthe residue is chromatographed on silica gel (cyclohexane/ethyl acetate 20:1->9:1)

出典と根拠

ORDレコード
ord-64982cd771ba48ec9549ceea381e2657
出典データセット
uspto-grants-2011_02
特許番号
US07879806B2

反応ノート

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