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Triethylamine → n-Butyl N-[chloro(4-chlorophenoxy)phosphoryl]-L-alaninate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | p-Chlorophenyl dichlorophosphate | HCID 69879 | — |
| 反応物 | L-Alanine, ethyl ester, hydrochloride (1:1) | HCID 2724356 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | n-Butyl N-[chloro(4-chlorophenoxy)phosphoryl]-L-alaninate | HCID 59157902 | — |
反応手順
Following the procedure described for Example 1, step 2, treatment of a solution in DCM (0.090 M) of the commercially available 4-chlorophenyl dichlorophosphate with L-alanine ethyl ester hydrochloride (1.0 eq.) and Et3N (2.0 eq.) provided the title compound as a colorless oil as a 1.1:1* mixture of diastereoisomers. 31P NMR (400 MHz, CDCl3): δ: 9.52 and 9.28*
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07879815B2 |
| 出典データセット | uspto-grants-2011_02 |
| ORD ID | ord-eaedf7c015764052a90ad976cd877017 |
| 出典メモ | uspto-grants-2011_02 |