関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-Aminoazetidine, 3-BOC protected | HCID 1519405 | — |
| 反応物 | 4-Bromo-2-methoxypyridine | HCID 14062309 | — |
| 試薬 | Sodium t-butoxide | HCID 23676156 | — |
| 触媒 | Binap, (A+-)- | HCID 634876 | — |
| 触媒 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | tert-butyl N-[1-(2-methoxy-4-pyridinyl)azetidin-3-yl]carbamate | HCID 118055029 | 100.28% |
反応手順
A mixture of all the reactants in toluene was heated in a sealed vial at 70 °C overnight. According to LC-MS the reaction was completed and the product had been formed. Toluene was removed, water was added and the product was extracted with DCM. The organic phase was dried through phase separator and concentrated. The crude was used without further purification in the next step, EN01762-02.
情報源と証拠
| 出典データセット | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-3870c5bc1f6548e38bd05a0e29b91f59 |
|---|
| 出典メモ | 750 AstraZeneca ELN dataset |
|---|
