Methanol → 4-Chloro-2-methyl-7-azaindole

HRID 1360186ノート

反応式

HRID 1360186 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[N:8](S(C3C=CC=CC=3)(=O)=O)[C:9]([CH3:11])=[CH:10][C:3]=12.C(=O)([O-])[O-].[K+].[K+].CO>O>[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[NH:8][C:9]([CH3:11])=[CH:10][C:3]=12

参加物

5

反応物 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 117383384-chloro-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

生成物 1

HCID 210816754-Chloro-2-methyl-7-azaindole収率 72%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
90 °C

実験手順

A mixture of 4-chloro-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (4.73 g), potassium carbonate (6.4 g), methanol (45 ml), and water (15 ml) was stirred at 90° C. for 2 hours. After the mixture was cooled, the obtained needle crystals were filtered and washed with water to obtain 4-chloro-2-methyl-1H-pyrrolo[2,3-b]pyridine (1.85 g).

後処理

  1. temperatureAfter the mixture was cooled
  2. filtrationthe obtained needle crystals were filtered
  3. washwashed with water

出典と根拠

ORDレコード
ord-00bc8e76fb284076b97a69894fbb7f2a
出典データセット
uspto-grants-2011_02
特許番号
US07879844B2

反応ノート

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