Phosphorus oxychloride → 6-Cyanopyridine-2-carboxylic acid

反応式

[C:1]([C:4]1[N:9]=[C:8]([C:10]([OH:12])=[O:11])[CH:7]=[CH:6][CH:5]=1)(=O)[NH2:2].P(Cl)(Cl)(Cl)=O>>[C:1]([C:4]1[N:9]=[C:8]([C:10]([OH:12])=[O:11])[CH:7]=[CH:6][CH:5]=1)#[N:2]

参加物

反応物 2

HCID 24813Phosphorus oxychloride

HCID 186766986-Carbamoylpyridine-2-carboxylic acid

生成物 1

HCID 212530396-Cyanopyridine-2-carboxylic acid

実験手順

6-Carbamoyl-pyridine-2-carboxylic acid (compound G1) (500 mg, 3 mmol) and phosphorus oxychloride (POCl3) (15 mL) are heated to reflux temperature for 2 h. The mixture is worked up in the usual manner and the crude product is further used without any purification.

後処理

temperatureto reflux temperature for 2 h
customthe crude product is further used without any purification

出典と根拠

ORDレコード: ord-f96aad530e67451382ebe34338fb2cad
出典データセット: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07879853B2

反応ノート

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