1,4-Dibromobutane → HCID 23160672、化合物

HRID 1360397ノート

反応式

HRID 1360397 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:4][CH:3]=1.Br[CH2:14][CH2:15][CH2:16][CH2:17]Br.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[N:1]1([C:2]2[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:6][CH:7]=2)[CH2:17][CH2:16][CH2:15][CH2:14]1

参加物

5

反応物 3

HCID 80561,4-DibromobutaneHCID 11430Potassium CarbonateHCID 2761030Methyl 2-(4-aminophenyl)acetate

生成物 1

HCID 23160672HCID 23160672、化合物収率 24.6%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
80 °C

実験手順

Methyl 4-aminophenylacetate (0.4 g, 2.4 mmol), 1,4-dibromobutane (0.29 mL, 2.4 mmol) and potassium carbonate (0.34 g, 2.6 mmol) were dissolved in dimethylformamide (30 mL), and the mixture was stirred overnight at 80° C. The solvent was evaporated, and the residue was worked up according to a conventional method and purified by silica gel column chromatography to give the title compound (0.13 g, 0.59 mmol).

後処理

  1. customThe solvent was evaporated
  2. custompurified by silica gel column chromatography

出典と根拠

ORDレコード
ord-22e24d29648a4978bb12c9986712b8c0
出典データセット
uspto-grants-2011_02
特許番号
US07879863B2

反応ノート

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