Phosphorus oxychloride → 1,5-diethyl-1H-pyrazole-3-carbonitrile
反応式
[CH2:1]([N:3]1[C:7]([CH2:8][CH3:9])=[CH:6][C:5]([C:10]([NH2:12])=O)=[N:4]1)[CH3:2].P(Cl)(Cl)(Cl)=O>>[CH2:1]([N:3]1[C:7]([CH2:8][CH3:9])=[CH:6][C:5]([C:10]#[N:12])=[N:4]1)[CH3:2]参加物
3
実験手順
1,5-Diethyl-1H-pyrazole-3-carboxamide (8.3 g, 0.050 mol) was treated with phosphorous oxychloride (35 mL) according to the method described in Part C of Example 7. The reaction was heated for 2.5 hours to provide 7.6 g of 1,5-diethyl-1H-pyrazole-3-carbonitrile as a yellow oil, which was used without purification.
後処理
- temperatureThe reaction was heated for 2.5 hours
出典と根拠
- ORDレコード
- ord-393ff205464c46a39a47a229701e82e6
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07879849B2
反応ノート
読み込み中…