Pyridine, 2,4,6-trichloro- → 2,6-Dichloro-4-methoxypyridine

HRID 1360673ノート

反応式

HRID 1360673 の反応式
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[CH:5]=[C:4]([Cl:9])[N:3]=1.C[O-].[Na+].[C:13](OCC)(=[O:15])C.O>CO>[Cl:1][C:2]1[CH:7]=[C:6]([O:15][CH3:13])[CH:5]=[C:4]([Cl:9])[N:3]=1

参加物

5

反応物 3

HCID 27665Pyridine, 2,4,6-trichloro-HCID 10942334Sodium MethoxideHCID 22728543Water ethylacetate

生成物 1

HCID 33199932,6-Dichloro-4-methoxypyridine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 2,4,6-trichloropyridine (4.5 g) in methanol was added sodium methoxide (25% in methanol, 6.8 mL) at room temperature. The mixture was stirred for 12 h then poured into ethyl acetate/water and separated. The organic layer was washed with water, brine and dried over magnesium sulfate. Upon evaporating, the residue was purified by crystallization (100% hexanes) to give title compound as solid (3.1 g).

後処理

  1. customseparated
  2. washThe organic layer was washed with water, brine
  3. dry with materialdried over magnesium sulfate
  4. customUpon evaporating
  5. customthe residue was purified by crystallization (100% hexanes)

出典と根拠

ORDレコード
ord-f5b3f16c56ba46f48aa34f6b160730c0
出典データセット
uspto-grants-2011_02
特許番号
US07879875B2

反応ノート

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