Thiazolidinedione → 5-(3,4-Dibromobenzylidene)thiazolidine-2,4-dione

HRID 1360986

反応式

HRID 1360986 の反応式
[S:1]1[CH2:5][C:4](=[O:6])[NH:3][C:2]1=[O:7].[Br:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][C:16]=1[Br:17])[CH:12]=O.N1CCCCC1>C(O)(=O)C>[Br:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][C:16]=1[Br:17])[CH:12]=[C:5]1[S:1][C:2](=[O:7])[NH:3][C:4]1=[O:6]

参加物

5

反応物 3

HCID 5437ThiazolidinedioneHCID 8082PiperidineHCID 6220533,4-Dibromobenzaldehyde

生成物 1

HCID 765458665-(3,4-Dibromobenzylidene)thiazolidine-2,4-dione

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of thiazolidine-2,4-dione (90%, 65 mg, 0.5 mmol), 3,4-dibromobenzaldehyde (132 mg, 0.5 mmol), and piperidine (247 μL, 2.5 mmol) was shaken in acetic acid (2 mL) at 110° C. for 16 hours. After cooling, the mixture was concentrated to dryness in vacuo. The resulting crude product was shaken with water, centrifuged, and the supernatant was discarded. Subsequently the residue was shaken with ethanol, centrifuged, the supernatant was discarded and the residue was further evaporated to dryness to afford the title compound.

後処理

  1. temperatureAfter cooling
  2. concentrationthe mixture was concentrated to dryness in vacuo
  3. stirringSubsequently the residue was shaken with ethanol
  4. customthe residue was further evaporated to dryness

出典と根拠

ORDレコード
ord-1368f77cd1ce4057b5c4f1e0728b3996
出典データセット
uspto-grants-2011_02
特許番号
US07879893B2

関連ノート

読み込み中…