Ammonia → HCID 19012449、化合物
反応式
[CH2:1]([C:5]1[NH:10][C:9](=[O:11])[C:8]([C:12]#[N:13])=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].N>CO.[Ni]>[NH2:13][CH2:12][C:8]1[C:9](=[O:11])[NH:10][C:5]([CH2:1][CH2:2][CH2:3][CH3:4])=[CH:6][CH:7]=1参加物
5
実験手順
intermediate (24a) (180 mg, 1 mmol) was dissolved in MeOH (10 mL). Aqueous ammonia (1 mL) was added, followed by wet Raney Nickel (100 mg). The mixture was stirred at room temperature under hydrogen for 3 hours. The mixture was then filtered and the filtrate evaporated to yield intermediate (24b) (157 mg, 870 μmol, which was used without further purification. MS m/z: [M+H+] calcd for C10H17N2O, 181.3; found 181.3.
後処理
- filtrationThe mixture was then filtered
- customthe filtrate evaporated
出典と根拠
- ORDレコード
- ord-e8f13e9f39024a85a6c62504dd6d551a
- 出典データセット
- uspto-grants-2011_02
- 特許番号
- US07879896B2
反応ノート
読み込み中…