関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1,5-Diiodopentane | HCID 12354 | — |
| 反応物 | Methyl 1-aminocyclopropanecarboxylate | HCID 2735309 | — |
| 触媒 | Tetrabutylammonium Bromide | HCID 74236 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | Methyl 1-piperidin-1-ylcyclopropanecarboxylate | HCID 14358246 | — |
反応手順
A mixture of methyl 1-aminocyclopropane-1-carboxylate (0.50 g, 4.35 mmoles), powdered potassium carbonate (2.40 g, 17.4 mmoles), and tetrabutylammonium bromide (0.140 g, 0.43 mmoles) in anhydrous acetonitrile (12 mL) was treated with 1,5-diiodopentane (1.70 g, 5.22 mmoles). The mixture was stirred for three days at 90° C. The mixture was cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure. The residue was purified on an Alltech pre-packed silica gel column eluting with ethyl acetate to afford the title compound. MS(DCI) m/z 184 (M+H)+. Vaidyanathan, G.; Wilson, J. W. J. Org. Chem. 1989, 54, 1810-1815.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07880001B2 |
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| 出典データセット | uspto-grants-2011_02 |
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| ORD ID | ord-a0c46971f4cd44e38d8cf99d50ad3fad |
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| 出典メモ | uspto-grants-2011_02 |
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